Studies evaluating the expression of classic pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-17, IL-18, IL-33) in the spinal cord, PAG, and DRG revealed upregulation following inoculation of cancer cells to establish the BCP models [20–23, 27, 37–40, 42–44]. The gene discussed is IL18; the disease is cancer.