The only few defense systems predicted to be also on plasmids were many of the abortive infection systems (Abi2, AbiD, AbiE, AbiQ, CBASS-I, CBASS-II, PifA, and PrrC) and some of the ones degrading nucleic acids (Nhi, RM-I, RM-II, RM-III, and Shedu, 40), dGTPase and BREX preventing phage DNA replication (37), and the uncharacterized GAO-19, Rst NACHT, and Rst Sirtuin-like. This evidence concerns the gene SLC22A12 and infection.