VHL and renal cell carcinoma: Transmembrane protein 52B (TMEM52B) (TMEM52B; gene ID, 120 939; chromosome location, 12p13.2; also termed C12orf59, FLJ31166 or MGC111385) was initially cloned in 2002 and is widely expressed in various normal human tissues, with its highest expression in the kidney.[11, 12] Our previous findings revealed that decreased TMEM52B expression is associated with poor prognosis and VHL mutation in human renal cell carcinoma (RCC),[12] indicating its role as a tumor suppressor in renal carcinogenesis.