In a recent study, TMEM52B was found to function as a tumor suppressor in colon cancer, where overexpression of both TMEM52B isoform 1 and isoform 2 reduced tumor growth and early metastasis in an EGFR‐dependent manner.[13] Despite current studies supporting a tumor‐suppressive role of TMEM52B in RCC and colon cancer, our recent sequencing results on NPC cells and normal nasopharyngeal cells show that TMEM52B is significantly upregulated in NPC cells, motivating us to investigate its potential oncogenic function in NPC. The gene discussed is TMEM52B; the disease is nasopharyngeal carcinoma.