Biallelic variants in the 4‐hydroxyphenylpyruvate dioxygenase‐like (HPDL) gene have been described in 2020 as able to cause a progressive disorder with variable clinical presentation, ranging from severe neonatal‐onset encephalopathy or infantile‐onset neurodegeneration with progressive spasticity and brain white matter abnormalities (NEDSWMA), to milder manifestation of adolescent‐onset pure hereditary spastic paraplegia (HSP) classified as SPG83.1 Here, HPDL is linked to hereditary spastic paraplegia.