Implication of HPDL protein in mitochondrial function and thiamine role in Krebs cycle,11 together with similar neuroimaging findings during acute decompensation in both HPDL‐related disorder and Wernicke encephalopathy, suggest a possible shared mechanism of energetic dysfunction that still needs to be assessed with novel basic research studies that could clarify HPDL‐related disorders pathophysiology. This evidence concerns the gene HPDL and Wernicke encephalopathy.