First, we identified 1373 brain-expressed HAR genes derived from a comparative genomic study of conserved loci with elevated divergence in humans versus chimpanzees and other mammals (Fig. 3A and Supplementary material).7 We next assessed the overlap between brain-expressed HAR genes and genes whose expression patterns correlated with atrophy in FTLD using Fisher's exact test. The gene discussed is LYVE1; the disease is Atrophy.