LYVE1 and Alzheimer disease: To evaluate the specificity of the overlap between HAR genes and FTLD atrophy-correlated genes, we leveraged a publicly available W-score map of cortical atrophy from 147 amyloid- and tau-confirmed patients with Alzheimer's disease-type dementia (henceforth, AD).48 This analysis revealed an overlap between HAR genes and AD atrophy-correlated genes, but this overlap did not reach significance and was statistically smaller that the overlap between HAR genes and random FTLD-TDP and FTLD-tau atrophy-correlated gene lists of same size as the AD atrophy-correlated genes (Supplementary Fig. 8).