Previous studies have shown that plasma GFAP levels are associated with Alzheimer's disease pathology measured in CSF12,21,26,27 and plasma21,26,28 and by neuroimaging.12,29 More specifically, GFAP has been suggested to play a role in the association between amyloid pathology and early deposition of neurofibrillary tau tangles.26 Moreover, GFAP has been shown to predict conversion from mild cognitive impairment to Alzheimer's disease dementia.27 This evidence concerns the gene GFAP and Alzheimer disease.