Although lower threshold points, such as the one used in this study, perform well in prevention studies56 and seem to be a better fit for APOE4 carrier patient selection for anti-amyloid studies,57 higher thresholds usually have the best agreement with neuropathological and clinicopathological evidence of Alzheimer's disease.58 Therefore, the selection of Centiloid threshold for amyloid status binarization should be assessed carefully, taking into consideration the study design and primary end point. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.