Trabeculation has been described as an EMT-like process (Jiménez-Amilburu et al., 2016), and thus breakdown of laminin at the basal ventricular surface is in line with basement membrane degradation in other EMT events from embryonic development to cancer metastasis (Kalluri and Weinberg, 2009; Zeisberg and Neilson, 2009; Banerjee et al., 2022; Amack, 2021). The gene discussed is LAMB2; the disease is cancer.