SSc‐associated autoantibodies (anti‐DBT, anti‐ CENP‐B, and anti‐CENP‐A) and anti‐CD320 antibody were detected at high levels only in the patient's serum, while autoantibodies to the following four proteins were detected in the sera of both the patient and her daughter: TRIM21, LIMS1, CLIP4, and KAT2A. This evidence concerns the gene KAT2A and systemic sclerosis.