metMHN also infers multiple positive interactions between gene mutations and corresponding copy number alterations, exemplified by the interaction between EGFR (M) and amplification of EGFR/7p, as well as between STK11 (M) and deletion of STK11/19p—a pattern commonly seen across various cancers (Becchi et al. 2023). The gene discussed is EGFR; the disease is cancer.