As well as being a transcriptional target for YAP/TAZ, NUAK2 was shown to inhibit LATS1 kinase activity, and acute treatment of cancer cells with the dual NUAK inhibitors, WZ4003 or HTH-02-006, increased YAP1S127 phosphorylation and blocked nuclear translocation of YAP1 [21,22]. This evidence concerns the gene NUAK2 and cancer.