In addition, while total number of CD4+ and CD8+ T cells were similar between MM patients and HD, we found a reduction in the absolute number of CD4+ and CD8+ naive T cells (TN) and an increase of CD4+ effector memory T cells (TEM) and TEMRA in MM patients (Figure 1(b), Supplementary Figure S1a). This evidence concerns the gene CD4 and Miyoshi myopathy.