KIF11 and hepatocellular carcinoma: Lastly, Cao and coworkers found that KIF11 overexpression in HCC could also be related to epigenetic modifications, such as DNA methylation; in fact, among the genes exhibiting hypomethylation KIF11 is included, confirming once again the strong relationship between Eg5 expression and HCC and shedding light on another possible mechanism able to explain this correlation [42].