In AD, the amount of two essential receptors for the correct development and function of the CNS, the Nerve Growth Factor/Neurotrophin receptor (NGF/NTR) and the N-methyl-D-aspartate receptor (NMDA), appears to decrease on the surface of neurons after Aβ accumulation; this effect is comparable to that observed after chemical inhibition of Eg5 by monastrol. The gene discussed is NGF; the disease is Alzheimer disease.