Furthermore, as previously reported for other tumor models, KIF11 knockdown determines the effect not only on mitotic activity, but also on nonmitotic activity: siKIF11 reduced the invasion of SKOV3 cells and modified the expression levels of epithelial to mesenchymal transition genes, such as an upregulation of E-cadherin mRNA expression and a downregulation of N-cadherin and vimentin mRNA levels [54]. The gene discussed is KIF11; the disease is neoplasm.