DNMT1 and metastatic melanoma: (26), microRNA expression chip analysis showed that miR-617 level was significantly upregulated in metastatic melanoma cells treated with 8 mM pharmacological dosage of ascorbate (inhibitor of DNMT) which is in congruence with the transcriptional reactivation of miR-617 post 5-Azacytidine treatment of SCC131 cells in the present study (Figure 1A).