FN1 and hemorrhagic disease: In comparison to uncoated substrates and Fn monolayer, Fn/PLL LbL films significantly improved human osteoblast-like and pre-osteoblast134 adhesion and proliferation.217,218 PRM, used for treating heparin overdose or excessive bleeding disorder, gives rise to hydrophilic coatings on silicon substrates with PSS as a polyanionic counterpart.