Furthermore, this study reveals that genistein down-regulates c-erbB-2, suppresses the secretion of MMP-2 and MMP-9 in a dose- and time-dependent manner, and mitigates tumor cell invasion in the context of Head and Neck Squamous Cell Carcinoma (HNSCC), concurrently reducing the levels of 14-3-3 and phosphorylated Akt [167]. This evidence concerns the gene MMP2 and head and neck squamous cell carcinoma.