Recently, ACSS2 is discovered to be reduced in the brain of patients with AD and mouse model, and it-mediated histone acetylation of N-methyl-d-aspartate receptors (NMDARs) and AMPA receptors (AMPARs) can restore synaptic plasticity and improve cognition function in mouse model of AD [27]. Here, ACSS2 is linked to Alzheimer disease.