ACSS2 and neuroblastoma: To investigate the actual brain SCFA regulation on ACSS2, we selected increasing SCFAs, which contain sodium acetate (NaAC; 0 to 10,000 μM; acetate), sodium propionate (NaPPA; 0 to 1,000 μM; propionate), and sodium butyrate (NaBA; 0 to 1,000 μM; butyrate), to examine the changes of ACSS2 with d-mannose as a known ACSS2 inducer in human neuroblastoma SH-SY5Y cells [28].