Based on the single-cell spatial transcriptomic landscape of vasculogenic etiology from different stages of HCC, we analyzed pro-angiogenic signal alterations in temporal and spatial dimensions that occurred during HCC progression, and found strong cellular communications between overexpressed GP73 HCC and endothelial cells with high pro-angiogenesis potential via multiple receptor–ligand interactions at the single-cell level, which was consistent with the validation performed by expanding HCC single-cell samples from public databases. The gene discussed is GOLM1; the disease is hepatocellular carcinoma.