Furthermore, by generating orthotopic xenograft mouse liver tumor models and monitoring tumor growth and metastasis via bioluminescence over a 6-week period, we found that knocked down STAT3 suppressed the tumorigenicity and metastasis of Hep3B-GP73-OE cells with weaker fluorescence intensity (Fig. 4G), suggesting that the down-regulation of STAT3 impaired GP73-induced tumor growth and metastasis in vivo. This evidence concerns the gene STAT3 and neoplasm.