SOAT1 and hepatocellular carcinoma: Single-cell spatial transcriptomic data showed that Janus kinase/signal transducer and activator of transcription (JAK/STAT) and angiogenic signals were activated in overexpressed GP73 HCC cell clusters (Fig. S4A and B), showing particularly high scores in GP73 HCC cell clusters 2, 6, 9, 22, 24, 26, and 27 (Fig. 4A) and exhibiting strong spatial activation in GP73 overexpression regions (Fig. 4B and Fig. S4C and D), suggesting that GP73 potentially activates the JAK/STAT pathway to stimulate HCC angiogenesis.