[13] reported that GP73 could directly bind and interact with epidermal growth factor receptor (EGFR) and serve as a specific cargo adaptor to assist EGFR/receptor tyrosine kinase (EGFR/RTK) recycling back to the plasma membrane for positive feedback, supporting the sustained activation of downstream kinases to promote HCC invasion and metastasis. This evidence concerns the gene GOLM1 and hepatocellular carcinoma.