AKT1 and neuropathy: In contrast, patients without linezolid-associated neuropathy had anincrease in genes associated with NRF2-mediated oxidative stress response, theATP-dependent DNA damage response, tyrosine kinase receptor signaling, MAPKsignaling, PI3K-AKT signaling, and the Il-1 pathway (Figure 4A, Supplementary Table 1).