NT5E and head and neck squamous cell carcinoma: Similarly, the levels of CD73 in EVs derived from head and neck squamous cell carcinoma (Lu et al., 2022; Theodoraki et al., 2018) or glioblastoma metastasis (Wang et al., 2021) patients have been shown to correlate with the severity of the disease, being higher at later stages and contributing to immunosuppression.