Primary inflammation caused by LPS promotes the secretion of the NF-κB mediator in the peritoneal cavity through TLR4 present on macrophages, neutrophils, and other immune cells, followed by a cascade of reactions such as the production of significant levels of tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8), thus promoting the development of endometriosis (Khan et al., 2018; Jeljeli et al., 2020). This evidence concerns the gene TNF and endometriosis.