TAC1 and Parkinson disease: In animal experiments, Jia et al. (63) found that electroacupuncture reduced the loss of dopaminergic neurons in the substantia nigra of unilateral medial forebrain bundle (MFB)-lesioned PD model rats, reversed the decrease in midbrain substance P levels and the increase in glutamic acid decarboxylase-67 (GAD 67) mRNA levels induced by the lesion, and significantly reduced abnormal movements in PD model rats.