IDH1 and neoplasm: In addition, we observed a large number of co-occurrence of tumor-associated genes in these genes; such as NF1 and TTN, PTEN; FUBP1 and IDH1, CIC; EGFR and TTN, PTEN; PTEN and TTN; CIC and IDH1; ATRX and IDH1, TP53; TP53 and IDH1, which may indicate that these genes are interdependent or synergistic and have important roles in tumorigenesis and development (Figure 6E).