We performed KEGG enrichment analysis on the high MAP2K3-expressing and low MAP2K3-expressing groups in the TCGA cohort and found that the high MAP2K3-expressing group was mainly associated with immune response and DNA repair pathways, and all these results suggest that high MAP2K3 expression levels are closely related to immune-related signaling pathways in gliomas. Here, MAP2K3 is linked to central nervous system cancer.