By analyzing the effect of MAP2K3 expression levels on chemokines in the tumor immune microenvironment, the results showed elevated expression of several chemokines in the MAP2K3 high expression group; such as CXCL10, CCR5, CCR10, CCL5, CCL7, CCR2, and CCL22 (Figure 7A, upper part). Here, CCL22 is linked to neoplasm.