F8 and von Willebrand disease (hereditary or acquired): Understanding this exposure–response relationship is important in achieving the long-term goal of individualizing rVWF dosing, which would enable better prediction of VWF:RCo activity, FVIII:C, and treatment effects, and potentially reduce costs.16, 17To our knowledge, this is the first analysis in which a statistically significant exposure–response relationship has been documented in adult patients with VWD.