This study aims to investigate potential sex differences in the association between lipid profile and the risk of symptomatic intracerebral hemorrhage (sICH) in patients with acute ischemic stroke (AIS) who received intravenous thrombolysis using recombinant tissue plasminogen activator (r-tPA).<h4>Methods</h4>This multicenter retrospective observational study analyzed patients with AIS treated with intravenous r-tPA. Here, PLAT is linked to intracerebral hemorrhage.