In addition, our analyses identified multiple genes in the Lands Cycle acyl chain remodeling pathway, which were associated with cognitive decline independent of amyloid-β (Aβ) load and tau tangle pathologies.<h4>Discussion</h4>Our studies highlight the critical differences in acyl chain remodeling in brain tissue from <i>APOEε4</i> carriers and individual non-carriers with MCI. Here, MAPT is linked to Mental deterioration.