GAPDH and infection: The rapid production of ROS in activated neutrophils, which requires increased pentose cycling, and thus increased G6PD activity, acts to promote NETosis via oxidative inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (13); this process can even be pathogenic when excessive, as in hyperinflammatory states such as severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2) infection (14).