As examples, emerging evidence links increased G6PD activity and PPP flux to hyper-functional dendritic cells in aplastic anemia (109), as well as pro-inflammatory activated T cells in rheumatoid arthritis (110); still other reports link G6PD deficiency to a range of immune phenotypes (111), including celiac disease (112) and asthma (113). The gene discussed is G6PD; the disease is celiac disease.