This is similar to what was observed in rodent models of experimental autoimmune encephalomyelitis (EAE), where expression of IL-1β activated and translocated NF-ΚB to the nucleus and induced expression of inflammatory cytokines, IL-1β and TNF-α, as well as the IL-10 (Tomczak et al., 2006; Lawrence, 2009; Goldmann et al., 2013; Zhou et al., 2020). The gene discussed is IL10; the disease is experimental autoimmune encephalomyelitis.