FER and acute myeloid leukemia: In addition, although several new drugs for the treatment of AML, particularly for elderly patients, have been approved in recent years, such as the FMS-like tyrosine kinase 3 inhibitors, venetoclax, glasdegib or Vyxeos, the medical needs of patients with relapsed or refractory (RR) AML continue to be unmet (1,2,8,9).