TIMER2.0 database analysis pinpointed PRDM1 as having the strongest correlation with M2 macrophage infiltration (r = 0.691), followed by TREM2 (r = 0.604), PLXDC2 (r = 0.528), and CTSC (r = 0.516), highlighting their potential as biomarkers or therapeutic targets in HCC treatment strategies focused on modulating the tumor microenvironment (Figures 5(b) and 5(c)). This evidence concerns the gene PLXDC2 and hepatocellular carcinoma.