In the phase II eligible population, the ORR was 86% among 14 patients with ROS1-rearranged disease (all but one with NSCLC), and an ORR of 57% among seven patients with ALK-rearranged tumors, including NSCLC, renal cell carcinoma, and CRC (Drilon et al. 2017). Here, ROS1 is linked to hereditary clear cell renal cell carcinoma.