Model derivation and evaluation were performed in independent training and testing data.<h4>Results</h4>A total of 488 FH variant carriers were identified using whole-exome sequencing of the <i>low-density lipoprotein receptor</i>, <i>apolipoprotein B, apolipoprotein E, proprotein convertase subtilisin/kexin type 9</i> genes. This evidence concerns the gene APOB and familial hyperaldosteronism.