TARDBP and nevus comedonicus syndrome: Particularly, the high frequency (65.8%) of HS among LATE-NC stage 3 cases supports the view that HS is the culmination of LATE-NC in subjects with abundant TDP-43 pathology.52 In the present study, diffuse neocortical LRP was strongly associated with LATE-NC (Table 3) and confirms the findings by Agrawal and coworkers53 in a large community-based sample.