Although age-associated TDP-43 accumulation in the brain is known to be common and associated with memory loss, a definition and description of LATE-NC is still debated.15,16 Comprehensive studies investigating LATE-NC prevalence, clinical correlations, and relationships with other common neuropathologies, including Alzheimer’s disease neuropathologic change (ADNC), hippocampal sclerosis (HS), Lewy body disease (LBD) and vascular changes, remain limited. This evidence concerns the gene TARDBP and nevus comedonicus syndrome.