TARDBP and nevus comedonicus syndrome: Currently, LATE-NC can only be definitively diagnosed at autopsy.13 Although TDP-43 pathology had been recognized as an independent factor influencing cognition in earlier studies,14 the term LATE-NC was introduced in the consensus article by Nelson et al. 3 in 2019 which, in addition to defining nomenclature, presented recommendations for the neuropathological staging system (stages 1–3) of LATE-NC.