ROC analysis showed that the AUC of PKCδ (AUC = 0.9009) was significantly larger than that of TNF‐α (AUC = 0.7661), IL‐1β (AUC = 0.7125), and IL‐6 (AUC = 0.7696), indicating that PKCδ performs better than classical inflammatory proteins in distinguishing AD from non‐AD subjects (Figure 1H). This evidence concerns the gene IL6 and Alzheimer disease.