However, BCAA deprivation combined with the use of eltrombopag, a drug targeting TFEB, can play a two‐pronged role in exogenous supply deprivation and endogenous utilisation blockade to inhibit the proliferation and development of pancreatic cancer to the greatest extent, providing a new direction for new therapeutic methods, such as targeted metabolic reprogramming of pancreatic cancer. This evidence concerns the gene TFEB and pancreatic neoplasm.