For example, CTNNB1 mutations characterized by weak WNT-β catenin signaling are associated with immune activation, whereas those that led to high level WNT-β catenin signaling are associated with an immune desertic TME phenotype.38 We also explored TMB, FGA as well other common gene and oncogenic pathway alterations in HCC, although none had impact on outcomes to ICI. Here, CTNNB1 is linked to hepatocellular carcinoma.