NFKB1 and metabolic disease: For example, several vitamins (e.g., B1, B2, B3, B5, C, D3, and E) have the potential to restore the inflammatory environment in metabolic diseases [64–66] and mediate the regulation of targets related to inflammatory pathways (e.g., MAPK, IKK, JNK, and NF-κB; Figure 6).