AKT1 and colorectal carcinoma: Suggesting that vitamin D3 plays a key role in the prevention of colorectal cancer (CRC) through core targets, the phosphatidylinositol 3-kinase- protein kinase B (PI3K-AKT), hypoxia-inducible factor 1 (HIF-1), and forkhead box protein (FoxO) pathways [28].