MSH6 and cancer: Lastly, mutational signature and oncodrive gene analyses showed that the computed mutational signature similarity in the primary and recurrent tumors were best matched the COSMI 3 signature (Aetiology of HRD) and had consistent candidate cancer driver genes of MSH2, NOTCH1 and MSH6.<h4>Conclusion</h4>The high genetic concordance of the short variants remains stable along OC recurrence.