Although it's suggested there is a relation with Neurofibromatosis type 1, there is still no consensus on whether Jaffe-Campanacci syndrome is a subtype or variant of neurofibromatosis-1(NF-1).<h4>Case presentation</h4>In this article, we present a case series of 2 patients. The gene discussed is NF1; the disease is Multiple non-ossifying fibromatosis.