His father had positive features of both Jaffe-Campanacci syndrome and NF-1, while his sister only had features of NF-1, so we presented both.<h4>Conclusion</h4>Jaffe-Campanacci has a clear relationship with type 1 neurofibromatosis, which still has to be genetically established. This evidence concerns the gene NF1 and Multiple non-ossifying fibromatosis.