Even though several reports have indicated that many cytokines, their receptors, and cytokine signaling effectors are engaged in the metastatic process [74], our findings revealed that prostate cancer patients, which were specifically clustered for a low cumulative expression of IL13RA2, GDF7, IL33, CXCL1, TNFRSF19, CXCL6, LIFR, CXCL5, IL7, TSLP, and TNFSF15, display poor survival rates respect to patients showing high levels of the aforementioned genes. This evidence concerns the gene CXCL1 and Familial prostate cancer.