PDGFRB and central nervous system cancer: Several genetic alterations, including alterations in the genes encoding vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and their receptors (VEGFR and PDGFR), have been confirmed in glioma, these genetic alterations are often considered to be involved in the malignant progression of glioma cells by affecting processes such as proliferation, growth, apoptosis and invasion.