KIF4A and central nervous system cancer: To further explore the possible pathways affected by WZ-3146 in glioma, we analyzed the effects of KIF4A on glioma signaling pathways by GSEA and found that KIF4A significantly affects the apoptosis signaling pathway in glioma, consistent with the finding that KIF4A knockdown can induce prostate and ovarian cancer cell apoptosis [33, 34].