Herein, we expanded the sample size to verify whether functional polymorphisms in the LMO1 gene (rs2168101 and rs11603024), LMO2 gene (rs2273799, rs3758640 and rs7933499) and LMO4 gene (rs3766019) were associated with Wilms tumor susceptibility in a five-center case‒control study for Chinese population. This evidence concerns the gene LMO1 and Nephroblastoma.