In brief, the current epidemiological genetic association study identified that several functional SNPs in the LMO family genes, namely, rs2168101 G > T and rs11603024 C > T in the LMO1 gene and rs7933499 G > A in the LMO2 gene, are significantly associated with susceptibility to Wilms tumor. This evidence concerns the gene LMO2 and Nephroblastoma.