Following the exclusion of SNPs significant in single-trait GWAS for SI, NS, ES, ASI, GERD, or in LD (LD r2 ≥ 0.02) with any previously reported significant SNPs, rs4382592 and rs9671376 emerged as novel "pleiotropic SNPs" associated with the joint phenotype of SI-GERD, mapping to the genes MED27 and TRAF3, respectively. Here, MED27 is linked to gastroesophageal reflux disease.