We also identified RNF123, RBM6, and SUOX as potential functional genes in these brain tissues through SMR analysis between SI, NS, and GERD, with RBM6 also identified in the Nucleus accumbens enriched for SI and GERD, and GMPPB additionally identified in the Cerebellar Hemisphere region. The gene discussed is GMPPB; the disease is gastroesophageal reflux disease.