Further co-localization analysis confirmed that rs4382592, rs200968, and rs1510719 all had shared loci between SI, NS, ES/ASI, and GERD (PPH3 + PPH4 > 0.8) (Table 2, Fig. 3), and the genes (MED27, HIST1H2BO, MAML3) mapped by these SNPs were labeled on the Manhattan plot (Supplementary Material—Figure S1-6). The gene discussed is MED27; the disease is gastroesophageal reflux disease.