Likewise, ablation of αSMA-high myCAFs, or deletion of type 1 collagen in myofibroblasts was shown to aggravate disease course in PDAC and experimental liver metastasis (Bhattacharjee et al, 2021; Chen et al, 2021; Ozdemir et al, 2014). The gene discussed is ACTA1; the disease is metastasis.