Of note, TGFβ signaling has been shown essential for the acquisition of classical myofibroblast phenotypes (Biffi et al, 2019; Elyada et al, 2019; Sahai et al, 2020; Tauriello et al, 2018; Tauriello et al, 2022) and in tumor cells, ZEB1 is a key mediator of TGFβ signaling (Krebs et al, 2017; Schuhwerk et al, 2022; Stemmler et al, 2019). This evidence concerns the gene TGFB1 and neoplasm.