CD8A and Alzheimer disease: To ascertain whether these effects were reproducible in another AD mouse model, we used knock-in mice carrying multiple mutations in the APP gene (APPNLGF) and observed a significant increase in CD8+ T cells, EdU+OLIG2+ cells, Serpina3n+ oligodendrocytes and BCAS1+ cells with swellings, and using EM more myelin abnormalities compared to control mice at 12 months of age (Extended Data Fig. 5).