Among the immune-related protein interactors of Kv1.3 that were measured by our MS studies, we nominated C3 and STAT1 as proteins of interest to be validated by Luminex based on their known role in several neuroinflammatory and neurodegenerative diseases (42, 43, 44, 45, 46, 47). Here, KCNA3 is linked to neurodegenerative disease.