The risk of a NIHSS score at discharge greater than 6.85 (moderate stroke) was higher in the group of patients with age older than 54 years, height taller than 161 cm, PT time ≤13.25 seconds, PT ratio ≤99, creatinine >83.67 μmol/L, FII Prothrombin and MTHFR-C677T wildtype, and NOTCH3 p.R544C heterozygous (RR=4.8, 95% CI 1.53-15.04; Pfisher=3.47×10-2). The gene discussed is NOTCH3; the disease is stroke disorder.