In this study, we aim to further investigate the possible association of selected variations (NOS3 (rs2070744), NOS1AP (rs10494366), REN (rs11240688), PLA2G4A (rs1015710), TCF7L2 (rs4506565, rs4132670, and rs7917983), ADRB1(rs1801252 and rs1801253), and PTPRD (rs4742610, rs10739150, and rs12346562) with hypertension in the Jordanian population and the effect on drug response and clinical symptoms. Here, NOS1AP is linked to hypertensive disorder.