Here, we assessed genotypic and allelic frequencies of several SNPs within different candidate genes: NOS3 (rs2070744), NOS1AP (rs10494366), REN (rs11240688), PLA2G4A (rs1015710), TCF7L2 (rs4506565, rs4132670, and rs7917983), ADRB1 (rs1801252 and rs1801253), and PTPRD (rs4742610, rs10739150, and rs12346562) and their association with hypertension in Jordanian community. This evidence concerns the gene TCF7L2 and hypertensive disorder.