TCF7L2 and hypertensive disorder: The haplotype analysis as shown in Table 5, reveals that the AG haplotype of ADRB1 (P = 0.017, OR = 1.44), the TTC of PTPRD (P = 0.0033, OR = 4.03), and the CAA of TCF7L2 (P = 0.012, OR = 6.79) are significantly associated with hypertension and may be considered protective factors.