GPC3, a carcinoembryonic antigen, overexpressed in HCC and involved in Wnt‐dependent cell proliferation, is a target for CAR (hYP7)‐T cells, which can eliminate GPC3‐positive HCC cells through perforin‐ and granzyme‐mediated apoptosis or Wnt signalling reduction in cancer cells.237, 238. This evidence concerns the gene GPC3 and hepatocellular carcinoma.