Studies using HBV or HCV‐related HCCs (scRNA‐seq) have revealed that CD8+ T cell clusters are more abundant in HBV or HCV‐related HCCs compared with non‐HBV/HCV‐related HCCs, with chronic HBV/HCV infection states associated with increased cytotoxic T cells (CTLs) exhaustion.125. Here, CD8A is linked to infection.