GPC3, a carcinoembryonic antigen, overexpressed in HCC and involved in Wnt‐dependent cell proliferation, is a target for CAR (hYP7)‐T cells, which can eliminate GPC3‐positive HCC cells through perforin‐ and granzyme‐mediated apoptosis or Wnt signalling reduction in cancer cells.237, 238. The gene discussed is PRF1; the disease is hepatocellular carcinoma.