In acute myocardial infarction, the activation of NLRP3 inflammasome is critical, as shown by the reduced extension of infarct size in Nlrp3−/− mice [61, 93], although its role in the ischemia–reperfusion (I/R) damage is still controversial [58, 123]. This evidence concerns the gene NLRP3 and myocardial infarction.