GPNMB in TME is mainly expressed by TAMs, can be cleaved into a soluble form by ADAM10 which then binds to CD44 receptor in cancer cells to induce release several chemokines (CXCL1, CXCL2, CCL2, CCL5 and CCL7) as well as cytokines (IL-6, IL-11, and IL-33) [26]. The gene discussed is GPNMB; the disease is cancer.